Skin Tests

Skin allergy testing is the most sensitive and accurate way to diagnose the cause of allergies, including sensitivity to pollens, molds, pet dander, dust, feathers, cockroaches, foods and the venoms of stinging insects such as wasps and fire ants.

Solutions extracted in a laboratory from an allergen (a substance which may cause an allergic reaction) are pricked or injected into the skin. Itching, redness and swelling at the skin test site within 15 minutes indicates a positive reaction. We immediately apply an anti-itch cream after the tests to quickly lessen the irritation.

Using the procedures in our office, most people do not find allergy skin testing painful. In fact, we are usually able to test even young children without significant discomfort.

Prick Skin Tests

These tests may be performed on the back or forearm. First, we clean the area with alcohol and make marks on the skin with a pen to identify the various allergens. We then use a small plastic device with a point that has been dipped into an allergen solution to make a tiny prick of the skin, making a separate prick for each allergen solution. After 15 minutes, we measure the swelling and redness at each prick site. Most people say the prick test feels like getting touched with the point of a pencil or a fingernail.


Blue plastic prick testing device above, reactions to allergens below.


Intradermal Skin Tests

If a prick test is negative to a particular allergen, more sensitive intradermal testing is done. A small amount of allergen extract is injected with a tiny needle under the skin of the upper arm, and we measure swelling and redness after 15 minutes.

We usually apply an anti-itch cream to the site of any positive reactions, which immediately lessens itching. Skin test reactions usually fade within one to two hours. Most people feel fine after skin tests and can return to work or school.


Immediately after skin tests are completed you will meet with Dr. Howland to discuss the results and treatment plan. You will be provided  a sheet showing your test results. Skin testing and discussion of your results usually takes 1½ to two hours.

Medications that Interfere with Allergy Skin Testing

Some medications interfere with allergy skin tests and SHOULD BE DISCONTINUED PRIOR TO TESTING:


Five days prior to testing, stop all over-the-counter allergy, cold and sleep medications (Allegra, Benadryl, Claritin, Clortrimeton, diphenhydramine, Zyrtec, etc.), and prescription antihistamines (Clarinex, Xyzal, etc.). This includes  nasal sprays containing antihistamines, such as azelastine, Astepro, Dymista and Patanase.


  • Older antidepressants like Elavil (amitryptyline) should be stopped three days prior to testing.
  • Newer antidepressants (Prozac, Zoloft, etc.) do not interfere with testing.

Most medications do not interfere with skin testing and may be continued.

Do Not Stop The Following:

  • Cortisone nasal sprays (fluticasone, Nasonex, Nasacort AQ, Qvar, Rhinocort, Veramyst, etc.)
  • Asthma medications (Albuterol, Flovent, Singulair, Advair, etc.)
  • Antibiotics
  • Eye drops for allergy (Patanol, Pazeo, Elestat, Zaditor, etc.)
  • Decongestants (Sudafed, Sudafed PE, etc.)
  • Oral steroids (Prednisone, Medrol, Prelone, etc.)
  • Birth control pills
  • Medicines for other conditions such as diabetes, arthritis, reflux, high blood pressure, etc.

We Do Not Perform Skin Testing on the Following Patients:

  • We do not perform skin tests during pregnancy but pregnant women can have allergy blood tests.
  • Patients taking beta blocker medications on a daily basis should not be skin tested or take allergy shots.

The chronic use of beta blocker medications (which may be prescribed for high blood pressure, heart conditions, glaucoma, migraine prevention, etc.) may hinder the effectiveness of treating systemic reactions to allergy skin testing or immunotherapy. We do not skin test patients who chronically take beta blocker medications, but these patients are eligible for allergy blood tests. Ask your pharmacist, prescribing physician or one of our nurses if you are not sure if your medication is a beta blocker. Discover More about Beta Blockers.